Getting Started

Run your first analysis

No account required. Results in under a minute.

1. Open the analyzer

Click Launch foldfunc from the homepage. A form will appear, fill in the fields and click Analyze sequence.

2. Input fields

Protein sequence

Required

A protein sequence in single-letter amino acid format. Spaces, newlines, and carriage returns are stripped automatically. Only the 20 standard amino acids are accepted (A C D E F G H I K L M N P Q R S T V W Y).

MKTIIALSYIFCLVFA...

Minimum 10 residues · Maximum 600 residues

Protein name

Optional

A common name or identifier for the protein (e.g. "Lysozyme", "BRCA1"). Used to search for relevant literature and provides context to the AI interpretation. Leave blank if unknown.

Lysozyme C

Mutation positions

Optional

Residue positions you want targeted mutation scoring for, entered as a comma-separated list of integers. Positions are 1-indexed (the first residue is position 1). If left blank, foldfunc will automatically select positions across the sequence.

14, 35, 52, 101

3. What you get back

3D structure — An interactive molecular viewer showing the predicted 3D fold, coloured by confidence (blue = high, red = low).

pLDDT score — A per-residue confidence score averaged across the full sequence. Ranges from 0–100.

Mutation heatmap — A colour-coded view of mutational tolerance at each scored position. Red = destabilising, green = tolerant.

AI biological interpretation — A structured summary covering protein family, key structural observations, and open research questions.

Literature context — Up to 3 abstracts retrieved for your protein name, used to ground the AI interpretation.

How it works →